What are the major causes of Narcolepsy?
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M$3 Answers
Researchers think that certain factors may work together to cause a lack of hypocretin. These factors may include:
* Heredity. Some people may inherit a gene that affects hypocretin. Up to 10 percent of people who have narcolepsy report having a relative with the same symptoms.
* Infections.
* Brain injuries due to conditions such as brain tumors or strokes.
* Contact with toxins, such as pesticides.
* Autoimmune disorders. These are conditions in which the body's immune system attacks the body's healthy cells. An example of an autoimmune disorder is rheumatoid arthritis.
Heredity alone doesn't cause narcolepsy. You also must have at least one other factor, such as one of those listed above, to develop narcolepsy.
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M$You can leave an optional "tip" with Mahalo's virtual currency, Mahalo Dollars. If you are asking a difficult question that might require some research, or if you'd like a wide variety of feedback, a higher tip often leads to more answers to your question.
M$The abnormalities in the hypocretin system could be responsible for the daytime sleepiness and abnormal REM sleep found in people with narcolepsy.
Those people who experienced narcolepsy have been found to have a markedly decrease number of hypocretin nerve cells and have decrease level of hypcoretins in the cerebrospinal flud.
Narcolepsy is also associated with a specific type of human leukocyte antigen. This finding of a very high HLA-associated in narcolepsy led to a proposal that it is an autoimmune disease similar to other HLA-associated diseases like multiple sclerosis and ankylosing spondylitis.
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